2017/07/01 by He Li, Li, He, Hung-Yu Chang +7
Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #Erythrocyte Function and Pathophysiology #FOS: Physical sciences #Lipid Membrane Structure and Behavior #Nanopore and Nanochannel Transport Studies #Soft Condensed Matter (cond-mat.soft)
paper · pdf · doi:10.48550/arxiv.1707.00218
openalex publication_date 2017/07/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
In this work, we review previously developed coarse-grained (CG) particle models for biological membrane and red blood cells (RBCs) and discuss the advantages of the CG particle method over the continuum and atomic simulations on modeling biological phenomena. CG particle models can largely increase the length scale and time scale of atomic simulations by eliminating fast degrees of freedom while preserving the mesoscopic structures and properties of the simulated system. One the other hand, CG particle models can be used to capture microstructural alternations in diseased RBCs and simulate topological changes of biological membrane and RBCs, which are major challenges to typical continuum representations of membrane and RBCs. The power and versatility of the CG particle methods are demonstrated through simulating the dynamical processes involving significant topological changes, such as lipid self-assembly, vesicle fusion and membrane budding.