Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms

2020/12/16 by Antonio Inserra, Danilo De Gregorio, Gabriella Gobbi · 230 citations
Medicine · Neuroscience · Psychology · #AMPA receptor #Dopamine #Dopaminergic #GABAergic #Glutamate receptor #Glutamatergic #Hallucinogen #Internal medicine #Medicine #Neuroplasticity #Neuroscience #Neurotransmitter Receptor Influence on Behavior #Pharmacology #Psychedelics and Drug Studies #Psychology #Receptor #Serotonergic #Serotonin #Tryptophan and brain disorders

paper · pdf · doi:10.1124/pharmrev.120.000056

published in Pharmacological Reviews 73(1), 202-277 (American Society for Pharmacology and Experimental Therapeutics)

openalex publication_date 2020/12/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Citations

• Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes
• Dose-Response Study of N,N-Dimethyltryptamine in Humans
• Brain-derived Neurotrophic Factor Regulates the Expression and Synaptic Delivery ofα-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunits in Hippocampal Neurons
• Pharmacogenomics Knowledge for Personalized Medicine
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• A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression
• Functional Selectivity and Classical Concepts of Quantitative Pharmacology
• Serotonin 5-Hydroxytryptamine2A Receptor Activation Suppresses Tumor Necrosis Factor-α-Induced Inflammation with Extraordinary Potency
• A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis
• Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer
• Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.
• Amphetamine, 3,4-Methylenedioxymethamphetamine, Lysergic Acid Diethylamide, and Metabolites of the Catecholamine Neurotransmitters Are Agonists of a Rat Trace Amine Receptor
• Increased thalamic resting‐state connectivity as a core driver of LSD‐induced hallucinations
• Psychiatry & the psychedelic drugs. Past, present & future
• Teaching, practising and testing listening comprehension using radio

Cited by

• Cellular mechanisms of serotonergic psychedelics - apical hypercontextualisation
• Neuroplasticity and psychedelics: A comprehensive examination of classic and non-classic compounds in pre and clinical models
• DMT-Induced Shifts in Criticality Correlate with Self-Dissolution
• The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation
• The separation distress hypothesis of depression – an update and systematic review
• Narrating the psychoneuroimmunomodulatory properties of serotonin 5-HT 2A receptor psychedelics from a transdiagnostic perspective
• Psychedelics and the future evolution of humanity
• Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine. [europepmc]
• Lysergic acid diethylamide differentially modulates the reticular thalamus, mediodorsal thalamus, and infralimbic prefrontal cortex: An in vivo electrophysiology study in male mice. [europepmc]
• Somatostatin interneurons activated by 5-HT 2A receptor suppress slow oscillations in medial entorhinal cortex. [europepmc]
• On the Relationship between Classic Psychedelics and Suicidality: A Systematic Review. [europepmc]
• Catalysts for change: the cellular neurobiology of psychedelics. [europepmc]
• Psychedelic perceptions: mental health service user attitudes to psilocybin therapy. [europepmc]
• Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics. [europepmc]
• Psychedelics, Sociality, and Human Evolution. [europepmc]
• Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder. [europepmc]
• Psychedelic-inspired approaches for treating neurodegenerative disorders. [europepmc]
• Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective. [europepmc]
• Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity. [europepmc]
• Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT. [europepmc]
• Classic Psychedelic Drugs: Update on Biological Mechanisms. [europepmc]
• Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline. [europepmc]
• Psychedelics and Neural Plasticity: Therapeutic Implications. [europepmc]
• Alleviating anxiety and taming trauma: Novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder. [europepmc]
• 5-HT2ARs Mediate Therapeutic Behavioral Effects of Psychedelic Tryptamines. [europepmc]
• Ketamine and serotonergic psychedelics: An update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment. [europepmc]
• Serotonergic psychedelics for depression: What do we know about neurobiological mechanisms of action? [europepmc]
• A non-hallucinogenic LSD analog with therapeutic potential for mood disorders. [europepmc]
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• Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics. [europepmc]
• The central role of the Thalamus in psychosis, lessons from neurodegenerative diseases and psychedelics. [europepmc]
• Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders. [europepmc]