Pharmacogenomics Knowledge for Personalized Medicine

2012/09/19 by M Whirl-Carrillo, Michelle Whirl‐Carrillo, E M McDonagh +13 · 1,858 citations
Biochemistry, Genetics and Molecular Biology · Computer Science · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Bioinformatics #Biology #Clinical pharmacology #Computational Drug Discovery Methods #Drug #Drug response #Gene #Genetics #Genotype #Medicine #Nutrition, Genetics, and Disease #Pathology #Personalized medicine #Pharmacogenetics #Pharmacogenetics and Drug Metabolism #Pharmacogenomics #Pharmacology #Precision medicine

paper · doi:10.1038/clpt.2012.96

published in Clinical Pharmacology & Therapeutics 92(4), 414-417 (Wiley)

openalex publication_date 2012/09/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05

Abstract

The Pharmacogenomics Knowledgebase (PharmGKB) is a resource that collects, curates, and disseminates information about the impact of human genetic variation on drug responses. It provides clinically relevant information, including dosing guidelines, annotated drug labels, and potentially actionable gene-drug associations and genotype-phenotype relationships. Curators assign levels of evidence to variant-drug associations using well-defined criteria based on careful literature review. Thus, PharmGKB is a useful source of high-quality information supporting personalized medicine-implementation projects.

Citations

• CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network

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