Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR)

2016/01/06 by Stine F. Pedersen, Yasunobu Okada, Bernd Nilius · 25 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Neuroscience · #Biochemistry #Biology #Cell #Cell biology #Cell type #Chemistry #Connexins and lens biology #Ion channel #Ion channel regulation and function #Neuroscience and Neuropharmacology Research #Receptor

paper · doi:10.1007/s00424-015-1781-6

openalex publication_date 2016/01/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

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• Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug Discovery. [europepmc]
• Specific and essential but not sufficient roles of LRRC8A in the activity of volume-sensitive outwardly rectifying anion channel (VSOR). [europepmc]
• The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pH. [europepmc]
• Amino acid homeostasis and signalling in mammalian cells and organisms. [europepmc]
• Comparative Effects of Chloride Channel Inhibitors on LRRC8/VRAC-Mediated Chloride Conductance. [europepmc]
• The signaling role for chloride in the bidirectional communication between neurons and astrocytes. [europepmc]
• ATP Release Channels. [europepmc]
• LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion. [europepmc]
• Downregulation of Leucine-Rich Repeat-Containing 8A Limits Proliferation and Increases Sensitivity of Glioblastoma to Temozolomide and Carmustine. [europepmc]
• LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs). [europepmc]
• Structure of the human volume regulated anion channel. [europepmc]
• Molecular Biology and Physiology of Volume-Regulated Anion Channel (VRAC). [europepmc]
• Cell Volume Control in Healthy Brain and Neuropathologies. [europepmc]
• Biophysics and Structure-Function Relationships of LRRC8-Formed Volume-Regulated Anion Channels. [europepmc]
• Contribution of Anoctamins to Cell Survival and Cell Death. [europepmc]
• Metabolic constraints of swelling-activated glutamate release in astrocytes and their implication for ischemic tissue damage. [europepmc]
• The Volume-Regulated Anion Channel LRRC8/VRAC Is Dispensable for Cell Proliferation and Migration. [europepmc]
• A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength. [europepmc]
• The LRRC8/VRAC anion channel facilitates myogenic differentiation of murine myoblasts by promoting membrane hyperpolarization. [europepmc]
• Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation. [europepmc]
• SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism. [europepmc]
• Ions, the Movement of Water and the Apoptotic Volume Decrease. [europepmc]
• Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 1: Roles of VSOR/VRAC in Cell Volume Regulation, Release of Double-Edged Signals and Apoptotic/Necrotic Cell Death. [europepmc]
• Dysregulation of Astrocyte Ion Homeostasis and Its Relevance for Stroke-Induced Brain Damage. [europepmc]
• Cholesterol regulation of mechanosensitive ion channels. [europepmc]