Loss-of-function of Nav1.8/D1639N linked to human pain can be rescued by lidocaine

2018/08/11 by Luisa Kaluza, Jannis Meents, Jannis E. Meents +9 · 8 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Ion channel regulation and function #Pain Mechanisms and Treatments #Neuroscience and Neural Engineering

paper · doi:10.1007/s00424-018-2189-x

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• Peripheral temperature dysregulation associated with functionally altered Na V 1.8 channels. [europepmc]
• Heterologous expression of the human wild-type and variant Na V 1.8 (A1073V) in rat sensory neurons. [europepmc]
• Nav1.8 and Chronic Pain: From Laboratory Animals to Clinical Patients. [europepmc]
• Applications of artificial intelligence in drug discovery for neurological diseases. [europepmc]