A commercial vaccine for ovine toxoplasmosis

1995/03/01 by D. Buxton, Elisabeth A. Innes, E. A. Innes · 26 citations
Immunology and Microbiology · Medicine · #Toxoplasma gondii Research Studies #Herpesvirus Infections and Treatments #Microbial infections and disease research

paper · doi:10.1017/s003118200000144x

Abstract

This paper describes the development of the first commercial vaccine for toxoplasmosis. The vaccine comprises live tachyzoites of the S48 'incomplete' strain of Toxoplasma gondii and is deployed to control toxoplasma abortion in sheep. A discussion of protective immune mechanisms and recent studies on host responses to the vaccine is also included.

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• Regulation of CD8+ T cell responses to infection with parasitic protozoa. [europepmc]
• Vaccines against Toxoplasma gondii: status, challenges and future directions. [europepmc]
• Compound DNA vaccine encoding SAG1/ SAG3 with A2/B subunit of cholera toxin as a genetic adjuvant protects BALB/c mice against Toxoplasma gondii. [europepmc]
• Protective immunity against Toxoplasma gondii induced by DNA immunization with the gene encoding a novel vaccine candidate: calcium-dependent protein kinase 3. [europepmc]
• Evaluation of immune responses in mice after DNA immunization with putative Toxoplasma gondii calcium-dependent protein kinase 5. [europepmc]
• Evaluation of immuno-efficacy of a novel DNA vaccine encoding Toxoplasma gondii rhoptry protein 38 (TgROP38) against chronic toxoplasmosis in a murine model. [europepmc]
• Vaccination of pigs with the S48 strain of Toxoplasma gondii--safer meat for human consumption. [europepmc]
• Vaccination with Toxoplasma gondii calcium-dependent protein kinase 6 and rhoptry protein 18 encapsulated in poly(lactide-co-glycolide) microspheres induces long-term protective immunity in mice. [europepmc]
• The common zoonotic protozoal diseases causing abortion. [europepmc]
• Induction of Protective Immunity against Toxoplasma gondii in Mice by Nucleoside Triphosphate Hydrolase-II (NTPase-II) Self-amplifying RNA Vaccine Encapsulated in Lipid Nanoparticle (LNP). [europepmc]
• Recombinant Tg HSP70 Immunization Protects against Toxoplasma gondii Brain Cyst Formation by Enhancing Inducible Nitric Oxide Expression. [europepmc]
• Parasite Carbohydrate Vaccines. [europepmc]
• SAG4 DNA and Peptide Vaccination Provides Partial Protection against T. gondii Infection in BALB/c Mice. [europepmc]
• Sixty Years (1957-2017) of Research on Toxoplasmosis in China-An Overview. [europepmc]
• Immune Protection of Rhoptry Protein 21 (ROP21) of Toxoplasma gondii as a DNA Vaccine Against Toxoplasmosis. [europepmc]
• A Lactate Fermentation Mutant of Toxoplasma Stimulates Protective Immunity Against Acute and Chronic Toxoplasmosis. [europepmc]
• Global initiative for congenital toxoplasmosis: an observational and international comparative clinical analysis. [europepmc]
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• A one health approach to vaccines against Toxoplasma gondii . [europepmc]
• RHΔ gra17 Δ npt1 Strain of Toxoplasma gondii Elicits Protective Immunity Against Acute, Chronic and Congenital Toxoplasmosis in Mice. [europepmc]
• Effective Nanoparticle-Based Nasal Vaccine Against Latent and Congenital Toxoplasmosis in Sheep. [europepmc]
• Comprehensive Overview of Toxoplasma gondii -Induced and Associated Diseases. [europepmc]
• Advances in vaccine development and the immune response against toxoplasmosis in sheep and goats. [europepmc]

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