Old vaccines, new usages, surprisingly effective in solving the century-old problem -Inactivated African Swine Fever Virus vaccine induces safe and efficient immune protection through mucosal immunity

2024/12/24 by Yang Jinlong, Jinlong, Yang, Yang JingXu +1
Agricultural and Biological Sciences · Medicine · #Animal Disease Management and Epidemiology #Biomolecules (q-bio.BM) #FOS: Biological sciences #Influenza Virus Research Studies #Vector-Borne Animal Diseases

paper · pdf · doi:10.48550/arxiv.2412.18223

openalex publication_date 2024/12/24 · openalex created_date 2024/12/26 · openalex updated_date 2026/07/28

Abstract

Background: African swine fever is among the most devastating viral diseases of pigs. Despite nearly a century of research, there is still no safe and effective vaccine available. The current situation is that either vaccines are safe but not effective, or they are effective but not safe.Findings: The ASF vaccine prepared using the inactivation method with propiolactone provided 98.6% protection within 100 days after three intranasal immunizations, spaced 7 days apart.Conclusions: An inactivated vaccine made from complete African swine fever virus particles using propiolactone is safe and effective for controlling ASF through mucosal immunity.

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