Pharmacological properties of SAK3, a novel T-type voltage-gated Ca2+ channel enhancer

2017/01/16 by Yasushi Yabuki, Kazuya Matsuo, Hisanao Izumi +7 · 15 citations
Neuroscience · Biochemistry, Genetics and Molecular Biology · #Neuroscience and Neuropharmacology Research #Ion channel regulation and function #Nicotinic Acetylcholine Receptors Study

paper · doi:10.1016/j.neuropharm.2017.01.011

Citations

• Requirement of dendritic calcium spikes for induction of spike‐timing‐dependent synaptic plasticity

Cited by

• T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice. [europepmc]
• Dopamine D 2L Receptor Deficiency Causes Stress Vulnerability through 5-HT 1A Receptor Dysfunction in Serotonergic Neurons. [europepmc]
• Neuroprotection of SAK3 on scopolamine-induced cholinergic dysfunction in human neuroblastoma SH-SY5Y cells. [europepmc]
• Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain. [europepmc]
• SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in App NL-G-F/NL-G-F Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling. [europepmc]
• The investigation of the T-type calcium channel enhancer SAK3 in an animal model of TAF1 intellectual disability syndrome. [europepmc]
• Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABA A Receptor. [europepmc]
• Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency. [europepmc]
• Single Administration of the T-Type Calcium Channel Enhancer SAK3 Reduces Oxidative Stress and Improves Cognition in Olfactory Bulbectomized Mice. [europepmc]
• T-Type Ca 2+ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model. [europepmc]
• Regulation of Hippocampal Gamma Oscillations by Modulation of Intrinsic Neuronal Excitability. [europepmc]
• Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators. [europepmc]
• The Anti-social Brain in Schizophrenia: A Role of CaMKII? [europepmc]
• Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024. [europepmc]
• Endothelin-3 and T-type Ca 2+ channels drive enteric neural crest cell calcium activity, contractility and migration. [europepmc]