2024/09/29 by Weistenhöfer, Wobbeke, Drexler, Hans, Hartwig, Andrea +1
#571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #Acetylcholinesterase #Acetylcholinesterase-Hemmer #Arbeitsstoff #BAT value #BAT-Wert #BLW #Biologischer Arbeitsstoff-Toleranzwert #Biologischer-Leitwert #Biomonitoring #Blut #Gefahrstoff #Toxizität #acetylcholinesterase inhibitors #biological guidance value #biological tolerance value #biomonitoring #blood #hazardous substance #occupational exposure #toxicity
paper · doi:10.34865/bb0astrinhd9_3ad
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) re-evaluated the biological tolerance value (BAT value) of acetylcholinesterase inhibitors, defined as a reduction in activity of no less than 70% of the reference value in erythrocytes. The BAT value is defined as a concentration at which the health of an employee generally is not adversely affected. However, it is not always clear whether the inhibition of acetylcholinesterase is the most sensitive toxicological endpoint of a substance or this has usually not been explicitly tested. The BAT value for the activity of acetylcholinesterase in erythrocytes is therefore suspended and continued as a biological guidance value (BLW). For substances for which it has been conclusively demonstrated that acetylcholinesterase inhibition in erythrocytes is the most sensitive endpoint, 70% of the reference value continues to be the BAT value.