2024/03/27 by Göen, Thomas, Drexler, Hans, Hartwig, Andrea +1
#1-Methoxy-2-hydroxyethan #1-Methoxy-2-hydroxyethane #2-Methoxyethan-1-ol #2-Methoxyethanol #2-Methoxyethyl acetate #2-Methoxyethylacetat #571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #Arbeitsstoff #BAT value #BAT-Wert #Biologischer Arbeitsstoff-Toleranzwert #Biomonitoring #EGME #EGMEA #Ethandiolmonomethylether #Ethanediol monomethyl ether #Ethylene glycol monomethyl ether #Ethylene glycol monomethyl ether acetate #Ethylenglykolmonomethylether #Ethylenglykolmonomethyletheracetat #Gefahrstoff #Glycol monomethyl ether #Glykolmonomethylether #Methoxyacetic acid #Methoxyessigsäure #Methyl cellosolve #Methyl glycol #Methylcellosolve #Methylglykol #Toxizität #Urin #biological tolerance value #biomonitoring #hazardous substance #occupational exposure #toxicity #urine
paper · doi:10.34865/bb10986e9_1ad
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) summarized and evaluated the data for 2-methoxyethanol [109-86-4] and 2-methoxyethyl acetate [110-49-6] to derive a biological tolerance value (BAT value) considering all toxicological end points. In 2008, the Commission derived a BAT value of 15 mg methoxyacetic acid/g creatinine for 2-methoxyethanol and 2-methoxyethyl acetate based on the haematotoxic effects in humans occupationally exposed to 2-methoxyethanol. In this article, new data on toxicity and toxicological mechanisms mainly regarding testicular toxicity are evaluated. The data are compliant with the former assessment that testicular toxicity is in the same order of magnitude as haematotoxicity. As a result, the BAT value of 15 mg methoxyacetic acid/g creatinine is confirmed. Sampling time is at the end of the shift on the last day of the working week after at least 2 weeks of exposure.