2023/01/31 by W K Jacky Lam, W.K. Lam, Ann D. King +59 · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Viral-associated cancers and disorders #Head and Neck Cancer Studies #Cancer-related molecular mechanisms research
paper · pdf · doi:10.1093/jnci/djad012
A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)-based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody and plasma EBV DNA testing methods were considered. Both approaches were found to have favorable performance characteristics and to be cost-effective in high-risk populations. In addition to endoscopy, use of magnetic resonance imaging (MRI) to investigate screen-positive individuals was found to increase the sensitivity of NPC detection with minimal impact on cost-effectiveness of the screening program.