2025/10/10 by Ilona Argirion, Aisha Babi, Julia Simon +11
Medicine · #Viral-associated cancers and disorders #Respiratory viral infections research #Lymphoma Diagnosis and Treatment
paper · doi:10.1093/infdis/jiaf526
Epstein-Barr virus (EBV) causes most nasopharyngeal carcinoma (NPC), a malignancy endemic in certain regions, presenting with nonspecific symptoms and lacking a robust minimally invasive biomarker. To assess previously developed multiplex Luminex assay EBV antibody signatures in a nonendemic population, we analyzed and compared 98 NPC sera and 142 matched controls from the nonendemic Head and Neck 5000 clinical cohort against an endemic Taiwan case-control cohort. All models, except the 2-antibody IgA panel, performed similarly, achieving 90%-99% accuracy in identifying EBV-positive NPC. Our results showed that EBV antibody panels can accurately define EBV-positive NPC regardless of endemicity.