Transgenic Animals with Inducible, Targeted Gene Expression in Brain

1998/09/01 by Jingshan Chen, Max B. Kelz, Guoqi Zeng +6 · 25 citations
Biochemistry, Genetics and Molecular Biology · #RNA Interference and Gene Delivery #Virus-based gene therapy research #CRISPR and Genetic Engineering

paper · doi:10.1124/mol.54.3.495

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• Full motor recovery despite striatal neuron loss and formation of irreversible amyloid-like inclusions in a conditional mouse model of Huntington's disease. [europepmc]
• DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation. [europepmc]
• Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction. [europepmc]
• Delta FosB-mediated alterations in dopamine signaling are normalized by a palatable high-fat diet. [europepmc]
• Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches. [europepmc]
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• Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity. [europepmc]
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• The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons. [europepmc]
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• Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. [europepmc]
• The role of Cdk5 in neuroendocrine thyroid cancer. [europepmc]
• A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ∆FosB Expression. [europepmc]
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• Early Restoration of Shank3 Expression in Shank3 Knock-Out Mice Prevents Core ASD-Like Behavioral Phenotypes. [europepmc]
• Sustained effects of rapidly acting antidepressants require BDNF-dependent MeCP2 phosphorylation. [europepmc]