Lactate and lactylation in cardiovascular diseases: current progress and future perspectives

2024/06/21 by Wengen Zhu, Siyu Guo, Junyi Sun +2 · 96 citations
Biochemistry, Genetics and Molecular Biology · Engineering · Medicine · #Adipose Tissue and Metabolism #Cardiovascular Function and Risk Factors #Current (fluid) #Engineering #Engineering ethics #Intensive care medicine #Medicine #Mitochondrial Function and Pathology

paper · doi:10.1016/j.metabol.2024.155957

published in Metabolism 158, 155957 (Elsevier BV)

openalex publication_date 2024/06/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Citations

• Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation
• Cardiac Energy Metabolism in Heart Failure
• GLUT-1/PKM2 loop dysregulation in patients with non-ST-segment elevation myocardial infarction promotes metainflammation
• Exercise-induced endothelial Mecp2 lactylation suppresses atherosclerosis via the Ereg/MAPK signalling pathway

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• H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes. [europepmc]
• L- and D-Lactate: unveiling their hidden functions in disease and health. [europepmc]
• Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model. [europepmc]
• High Sugar Induced RCC2 Lactylation Drives Breast Cancer Tumorigenicity Through Upregulating MAD2L1. [europepmc]
• The role of protein lactylation in brain health and disease: current advances and future directions. [europepmc]
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• Atlas of lysine propionylation of human right atrium and ALDH6A1-NADH pathway in new-onset atrial fibrillation after coronary surgery. [europepmc]
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• Dual role of lactate in human health and disease. [europepmc]
• Glycolysis to lactylation: Unraveling the metabolic and epigenetic landscape in tissue fibrosis (Review). [europepmc]
• Prognostic role of creatine kinase-MB in elderly patients with sepsis. [europepmc]
• Reprogrammed glucose metabolism in vascular smooth muscle cells and its implications for vascular diseases. [europepmc]
• HuoXue QianYang QuTan recipe attenuates myocardial hypertrophy in obese hypertensive rats by regulating MPC1/MCT4 mediated pyruvate-lactate metabolic axis. [europepmc]
• Lactylation modification regulates acute myeloid leukemia pathogenesis and immune microenvironment. [europepmc]
• Early arterial lactate trajectories and mortality risk in critically ill heart failure: a two-cohort trajectory analysis. [europepmc]
• Hyperglycemia exacerbates osteoarthritis by impairing macrophage efferocytosis through modulation of CD11b lactylation. [europepmc]
• Trained immunity attenuated acute lung injury by activating alveolar macrophages via AKT2-PDK1 axis-mediated metabolic reprogramming. [europepmc]
• Lactate metabolism and protein lactylation in cancer. [europepmc]
• Metabolic reprogramming in fibrosis-related diseases: underlying mechanisms and therapeutics. [europepmc]