Carnosol and Carnosic Acids from Salvia officinalis Inhibit Microsomal Prostaglandin E2 Synthase-1

2012/04/17 by Julia Bauer, Susanne Kuehnl, Judith M. Rollinger +5 · 25 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Antioxidant #Arachidonic acid #Biochemistry #Carnosic acid #Chemistry #Enzyme #Inflammatory mediators and NSAID effects #Microsome #Natural product bioactivities and synthesis #Officinalis #Plant biochemistry and biosynthesis #Prostaglandin E #Rosmarinic acid #Salvia officinalis #Traditional medicine

paper · doi:10.1124/jpet.112.193847

openalex publication_date 2012/04/17 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/26

Citations

• Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes

Cited by

• Carnosic acid
• Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs. [europepmc]
• Identification of natural compound carnosol as a novel TRPA1 receptor agonist. [europepmc]
• Towards Elucidating Carnosic Acid Biosynthesis in Lamiaceae: Functional Characterization of the Three First Steps of the Pathway in Salvia fruticosa and Rosmarinus officinalis. [europepmc]
• Combined metabolome and transcriptome profiling provides new insights into diterpene biosynthesis in S. pomifera glandular trichomes. [europepmc]
• Review of Anti-Inflammatory Herbal Medicines. [europepmc]
• Rosmarinic acid potentiates carnosic acid induced apoptosis in lung fibroblasts. [europepmc]
• GC/MS-Based Metabolomics Reveals Biomarkers in Asthma Murine Model Modulated by Opuntia humifusa . [europepmc]
• Extraction of Carnosic Acid and Carnosol from Sage (Salvia officinalis L.) Leaves by Supercritical Fluid Extraction and Their Antioxidant and Antibacterial Activity. [europepmc]
• Bioactive Profile of Various Salvia officinalis L. Preparations. [europepmc]
• Salvia officinalis , Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice. [europepmc]
• Discovery of a Novel Natural Allosteric Inhibitor That Targets NDM-1 Against Escherichia coli . [europepmc]
• Targeting microsomal prostaglandin E synthase 1 to develop drugs treating the inflammatory diseases. [europepmc]
• Determination of Suitable Macroporous Resins and Desorbents for Carnosol and Carnosic Acid from Deep Eutectic Solvent Sage ( Salvia officinalis ) Extract with Assessment of Antiradical and Antibacterial Activity. [europepmc]
• Lamiaceae in Mexican Species, a Great but Scarcely Explored Source of Secondary Metabolites with Potential Pharmacological Effects in Pain Relief. [europepmc]
• Anti- Heliobacter pylori and Anti-Inflammatory Potential of Salvia officinalis Metabolites: In Vitro and In Silico Studies. [europepmc]
• Anti-Inflammatory Therapeutic Mechanisms of Natural Products: Insight from Rosemary Diterpenes, Carnosic Acid and Carnosol. [europepmc]
• Carnosic Acid Ameliorates Indomethacin-Induced Gastric Ulceration in Rats by Alleviating Oxidative Stress and Inflammation. [europepmc]
• A Validated HPLC-UV-ESI-IT-MS Method for the Quantification of Carnosol in Lepechinia mutica , a Medicinal Plant Endemic to Ecuador. [europepmc]
• From Plant to Chemistry: Sources of Active Opioid Antinociceptive Principles for Medicinal Chemistry and Drug Design. [europepmc]
• Natural Compounds of Salvia L. Genus and Molecular Mechanism of Their Biological Activity. [europepmc]
• Salvia officinalis L. exerts oncostatic effects in rodent and in vitro models of breast carcinoma. [europepmc]
• Role of β-Lactamase Inhibitors as Potentiators in Antimicrobial Chemotherapy Targeting Gram-Negative Bacteria. [europepmc]
• Therapeutic Applications for Homeopathy in Clinical Practice. [europepmc]
• Prospecting Pharmacologically Active Biocompounds from the Amazon Rainforest: In Vitro Approaches, Mechanisms of Action Based on Chemical Structure, and Perspectives on Human Therapeutic Use. [europepmc]