The Effect of Periodontal Treatment on Serum Leptin, Interleukin‐6, and C‐Reactive Protein

2010/04/07 by Yasuko Shimada, Yasutaka Komatsu, Ikuyo Ikezawa‐Suzuki +3 · 26 citations
Dentistry · Medicine · Neuroscience · #Adiponectin #Adipose tissue #Body mass index #C-reactive protein #Chronic periodontitis #Clinical attachment loss #Cytokine #Endocrinology #Inflammation #Insulin resistance #Interleukin #Interleukin 6 #Internal medicine #Leptin #Medicine #Obesity #Oral microbiology and periodontitis research #Periodontitis #Regulation of Appetite and Obesity #Salivary Gland Disorders and Functions

paper · doi:10.1902/jop.2010.090741

openalex publication_date 2010/04/07 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25

Abstract

BACKGROUND: Previous studies suggest that periodontitis is closely related to obesity and metabolic syndrome. Leptin, a pleiotrophic hormone produced by adipose tissue, has been reported to be related to periodontitis. This study investigates the effects of periodontal treatment on the serum levels of leptin and other cytokines in patients with chronic periodontitis (CP). METHODS: Serum samples were taken from 33 CP patients (22 non-smokers, 11 smokers) and 18 healthy subjects. The serum leptin, adiponectin, tumor necrosis factor-alpha, interleukin (IL)-6, and C-reactive protein (CRP) levels were measured before and after non-surgical periodontal treatment. RESULTS: Significant differences between healthy and CP patients were found in serum leptin, IL-6, and CRP levels (P = 0.0018, P = 0.0064, and P = 0.0095, respectively). The serum leptin level was associated with mean probing depth, mean clinical attachment level, mean alveolar bone loss, and body mass index. There were significant associations between serum leptin levels and IL-6 and CRP levels. After non-surgical periodontal treatment, serum leptin, IL-6, and CRP levels were significantly decreased (mean +/- SD before and after, P value, respectively: leptin, 8.02 +/- 5.5, 7.10 +/- 4.4, P = 0.015; IL-6, 1.73 +/- 1.02, 1.36 +/- 0.73, P = 0.048; and CRP, 802.0 +/- 1065, 491.2 +/- 479.3, P = 0.047). CONCLUSIONS: Periodontal treatment is effective in reducing serum leptin, IL-6, and CRP levels. The results suggest that leptin, IL-6, and CRP could be mediating factors that connect metabolic syndrome and periodontitis.

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