A Real-Time Digital Twin for Type 1 Diabetes using Simulation-Based Inference

2025/07/02 by Trung-Dung Hoang, Hoang, Trung-Dung, Alceu Bissoto +11
Computer Science · Engineering · Health Professions · #Advanced Data Processing Techniques #Artificial Intelligence in Healthcare #Engineering Education and Technology #FOS: Biological sciences #FOS: Computer and information sciences #Machine Learning (cs.LG) #Quantitative Methods (q-bio.QM)

paper · pdf · doi:10.48550/arxiv.2507.01740

openalex publication_date 2025/07/02 · openalex created_date 2025/10/20 · openalex updated_date 2026/07/28

Abstract

Accurately estimating parameters of physiological models is essential to achieving reliable digital twins. For Type 1 Diabetes, this is particularly challenging due to the complexity of glucose-insulin interactions. Traditional methods based on Markov Chain Monte Carlo struggle with high-dimensional parameter spaces and fit parameters from scratch at inference time, making them slow and computationally expensive. In this study, we propose a Simulation-Based Inference approach based on Neural Posterior Estimation to efficiently capture the complex relationships between meal intake, insulin, and glucose level, providing faster, amortized inference. Our experiments demonstrate that SBI not only outperforms traditional methods in parameter estimation but also generalizes better to unseen conditions, offering real-time posterior inference with reliable uncertainty quantification.

Citations

• Simulation-based Inference for Cardiovascular Models
• Peregrine: Sequential simulation-based inference for gravitational wave signals
• Normalizing Flows for Probabilistic Modeling and Inference
• Flexible statistical inference for mechanistic models of neural dynamics
• Masked Autoregressive Flow for Density Estimation
• Fast ε-free Inference of Simulation Models with Bayesian Conditional Density Estimation

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