The role of myosin V in exocytosis and synaptic plasticity

2010/11/15 by Rüdiger Rudolf, Claudia Margarethe Bittins, Margarethe Bittins +2 · 25 citations
Biochemistry, Genetics and Molecular Biology · #Cellular transport and secretion #Ion channel regulation and function #Signaling Pathways in Disease

paper · pdf · doi:10.1111/j.1471-4159.2010.07110.x

Abstract

In neuroscience, myosin V motor proteins have attracted attention since they are highly expressed in brain, and absence of myosin Va in man leads to a severe neurological disease called Griscelli syndrome. While in some cells myosin V is described to act as a vesicle transport motor, an additional role in exocytosis has emerged recently. In neurons, myosin V has been linked to exocytosis of secretory vesicles and recycling endosomes. Through these functions, it is implied in regulating important brain functions including the release of neuropeptides by exocytosis of large dense-core vesicles and the insertion of neurotransmitter receptors into post-synaptic membranes. This review focuses on the role of myosin V in (i) axonal transport and stimulated exocytosis of large dense-core vesicles to regulate the secretion of neuroactive substances, (ii) tethering of the endoplasmic reticulum at cerebellar synapses to permit long-term depression, (iii) recycling of α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors at hippocampal synapses during long-term potentiation, and (iv) recycling of nicotinic acetylcholine receptors at the neuromuscular junction. Myosin V is thus discussed as an important modulator of synaptic plasticity.

Citations

• Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

Cited by

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• Myrip couples the capture of secretory granules by the actin-rich cell cortex and their attachment to the plasma membrane. [europepmc]
• Interactions between Leishmania braziliensis and Macrophages Are Dependent on the Cytoskeleton and Myosin Va. [europepmc]
• A Rab11a-Rab8a-Myo5B network promotes stretch-regulated exocytosis in bladder umbrella cells. [europepmc]
• A myosin-Va tail fragment sequesters dynein light chains leading to apoptosis in melanoma cells. [europepmc]
• Lithium's role in neural plasticity and its implications for mood disorders. [europepmc]
• Structural insights into functional overlapping and differentiation among myosin V motors. [europepmc]
• The cortical acto-Myosin network: from diffusion barrier to functional gateway in the transport of neurosecretory vesicles to the plasma membrane. [europepmc]
• The novel proteins Rng8 and Rng9 regulate the myosin-V Myo51 during fission yeast cytokinesis. [europepmc]
• The role of rab proteins in neuronal cells and in the trafficking of neurotrophin receptors. [europepmc]
• Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex. [europepmc]
• The molecular motor Myosin Va interacts with the cilia-centrosomal protein RPGRIP1L. [europepmc]
• Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model. [europepmc]
• Beta-2 Adrenergic Receptor Agonists Enhance AChR Clustering in C2C12 Myotubes: Implications for Therapy of Myasthenic Disorders. [europepmc]
• Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses. [europepmc]
• Myosin Va transport of liposomes in three-dimensional actin networks is modulated by actin filament density, position, and polarity. [europepmc]
• Knockdown of microRNA‑143‑5p by STTM technology affects eumelanin and pheomelanin production in melanocytes. [europepmc]
• Mechanism underlying hippocampal long-term potentiation and depression based on competition between endocytosis and exocytosis of AMPA receptors. [europepmc]
• Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses. [europepmc]
• Arabidopsis myosin XIK interacts with the exocyst complex to facilitate vesicle tethering during exocytosis. [europepmc]
• Role of actin cytoskeleton in the organization and function of ionotropic glutamate receptors. [europepmc]
• Comparison of Different Mass Spectrometry Workflows for the Proteomic Analysis of Tear Fluid. [europepmc]
• Molecular Mechanisms of AMPA Receptor Trafficking in the Nervous System. [europepmc]
• Localized, highly efficient secretion of signaling proteins by migrasomes. [europepmc]

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