Structures of Dimeric GIT1 and Trimeric β-PIX and Implications for GIT–PIX Complex Assembly

2008/12/31 by Oliver Schlenker, Katrin Rittinger · 69 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Biochemistry #Biology #Cell biology #Chemistry #Coiled coil #Dimer #GTPase #Guanine nucleotide exchange factor #Melanoma and MAPK Pathways #Multiprotein complex #Protein Kinase Regulation and GTPase Signaling #Receptor Mechanisms and Signaling #Scaffold protein #Signal transduction #Trimer

paper · doi:10.1016/j.jmb.2008.12.050

published in Journal of Molecular Biology 386(2), 280-289 (Elsevier BV)

openalex publication_date 2008/12/31 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/29

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• Role of βPix in the Kidney. [europepmc]
• βPix is a New Player in Renal Physiology. [europepmc]
• RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly. [europepmc]
• Specific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5. [europepmc]
• αPIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor. [europepmc]
• Affinity Enhancement by Ligand Clustering Effect Inspired by Peptide Dendrimers-Shank PDZ Proteins Interactions. [europepmc]
• Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes. [europepmc]
• Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity. [europepmc]
• MicroRNA-34c Suppresses Breast Cancer Migration and Invasion by Targeting GIT1. [europepmc]
• The Arf-GAP and protein scaffold Cat1/Git1 as a multifaceted regulator of cancer progression. [europepmc]
• GIT1 regulates synaptic structural plasticity underlying learning. [europepmc]
• Spatial intratumoural heterogeneity in the expression of GIT1 is associated with poor prognostic outcome in oestrogen receptor positive breast cancer patients with synchronous lymph node metastases. [europepmc]
• Paxillin phosphorylation at serine 273 and its effects on Rac, Rho and adhesion dynamics. [europepmc]
• SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis. [europepmc]
• Instability in a coiled-coil signaling helix is conserved for signal transduction in soluble guanylyl cyclase. [europepmc]
• Rac activation is key to cell motility and directionality: An experimental and modelling investigation. [europepmc]
• Spitzenkörper assembly mechanisms reveal conserved features of fungal and metazoan polarity scaffolds. [europepmc]
• Specific Isoforms of the Guanine-Nucleotide Exchange Factor dPix Couple Neuromuscular Synapse Growth to Muscle Growth. [europepmc]
• The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells. [europepmc]
• Kinesin-1-dependent transport of the βPIX/GIT complex in neuronal cells. [europepmc]
• UBTF facilitates melanoma progression via modulating MEK1/2-ERK1/2 signalling pathways by promoting GIT1 transcription. [europepmc]
• Regulation of androgen receptor stability by the β 1 Pix/STUB1 complex. [europepmc]
• Oligomerization and exocyst coupling underlie Spa2-mediated focusing of polarized growth in fission yeast. [europepmc]
• THRAP3 promotes ferroptosis resistance in acute myelocytic leukemia through SLU7-mediated alternative splicing of GIT2. [europepmc]
• Arhgef7 is essential for granule cell precursor proliferation and migration during cerebellum development. [europepmc]