From the one-carbon amide formamide to RNA all the steps are prebiotically possible

2012/02/22 by Raffaele Saladino, Giorgia Botta, Samanta Pino +2 · 37 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · Physics and Astronomy · #Amide #Biochemistry #Chemistry #Combinatorial chemistry #DNA #Enzyme Structure and Function #Formamide #Gene #Guanine #Nucleic acid #Nucleotide #Oligonucleotide #Organic chemistry #Origins and Evolution of Life #RNA #RNA and protein synthesis mechanisms #Residue (chemistry) #Stereochemistry

paper · doi:10.1016/j.biochi.2012.02.018

published in Biochimie 94(7), 1451-1456 (Elsevier BV)

openalex publication_date 2012/02/22 · crossref created 2012/02/22 · crossref issued 2012/07/01 · crossref published 2012/07/01 · crossref published-print 2012/07/01 · crossref deposited 2021/12/30 · openalex created_date 2025/10/10 · crossref indexed 2026/01/08 · openalex updated_date 2026/07/29

Citations

• The Ribosome Is a Ribozyme
• The origin of the genetic code and of the earliest oligopeptides
• Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions
• RNA-Catalyzed RNA Polymerization: Accurate and General RNA-Templated Primer Extension
• Multiple translational products from a five-nucleotide ribozyme
• Prebiotic Chemistry and the Origin of the RNA World
• Understanding Nucleic Acids Using Synthetic Chemistry

Cited by

• High-energy chemistry of formamide: A unified mechanism of nucleobase formation
• Abiogenesis [wikipedia]