1999/05/01 by Michael Forgac · 305 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #ATP Synthase and ATPases Research #Mitochondrial Function and Pathology #Photosynthetic Processes and Mechanisms #Endosome #Endocytic cycle #Intracellular #Endocytosis #Cell biology #Biology #Lysosome #Receptor #ATPase #Cytosol #Chemistry #Biochemistry #Enzyme
paper · pdf · doi:10.1074/jbc.274.19.12951
published in Journal of Biological Chemistry 274(19), 12951-12954 (Elsevier BV)
openalex publication_date 1999/05/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
The vacuolar (H+)-ATPases (or V-ATPases) are a family of ATP-dependent proton pumps that are responsible for acidification of intracellular compartments in eukaryotic cells (1-3). Acidification of vacuolar compartments plays an important role in a variety of cellular processes, particularly membrane traffic processes. In receptor-mediated endocytosis, acidification of endosomes serves as a signal that activates release of internalized ligands (such as low density lipoprotein and insulin) from their receptors.