2022/12/06 by Piaoe Zeng, Chao Qu, Jianfang Liu +4 · 9 citations
Medicine · #Cancer #Cholangiocarcinoma and Gallbladder Cancer Studies #Internal medicine #Intraclass correlation #Magnetic resonance imaging #Medicine #Nuclear medicine #Pancreatic and Hepatic Oncology Research #Pancreatic cancer #Pancreatic ductal adenocarcinoma #Radiology #Radiomics #Radiomics and Machine Learning in Medical Imaging
paper · doi:10.1177/02841851221142552
published in Acta Radiologica 64(7), 2221-2228 (SAGE Publishing)
crossref issued 2022/12/06 · crossref published 2022/12/06 · crossref published-online 2022/12/06 · openalex publication_date 2022/12/06 · crossref created 2022/12/07 · crossref published-print 2023/07/01 · openalex created_date 2025/10/10 · crossref deposited 2026/04/28 · crossref indexed 2026/08/03 · openalex updated_date 2026/08/04
BACKGROUND: The preoperative prediction of lymph node metastasis (LNM) in pancreatic ductal adenocarcinoma (PDAC) is essential in prognosis and treatment strategy formulation. PURPOSE: To compare the performance of computed tomography (CT) and magnetic resonance imaging (MRI) radiomics models for the preoperative prediction of LNM in PDAC. MATERIAL AND METHODS: In total, 160 consecutive patients with PDAC were retrospectively included, who were divided into the training and validation sets (ratio of 8:2). Two radiologists evaluated LNM basing on morphological abnormalities. Radiomics features were extracted from T2-weighted imaging, T1-weighted imaging, and multiphase contrast enhanced MRI and multiphase CT, respectively. Overall, 1184 radiomics features were extracted from each volume of interest drawn. Only features with an intraclass correlation coefficient ≥0.75 were included. Three sequential feature selection steps-variance threshold, variance thresholding and least absolute shrinkage selection operator-were repeated 20 times with fivefold cross-validation in the training set. Two radiomics models based on multiphase CT and multiparametric MRI were built with the five most frequent features. Model performance was evaluated using the area under the curve (AUC) values. RESULTS: Multiparametric MRI radiomics model achieved improved AUCs (0.791 and 0.786 in the training and validation sets, respectively) than that of the CT radiomics model (0.672 and 0.655 in the training and validation sets, respectively) and of the radiologists' assessment (0.600-0.613 and 0.560-0.587 in the training and validation sets, respectively). CONCLUSION: Multiparametric MRI radiomics model may serve as a potential tool for preoperatively evaluating LNM in PDAC and had superior predictive performance to multiphase CT-based model and radiologists' assessment.