Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA reductase

2020/10/27 by Marco De Giorgi, Kelsey E. Jarrett, Jason C. Burton +10 · 10 citations
Biochemistry, Genetics and Molecular Biology · #Coenzyme Q10 studies and effects #Mitochondrial Function and Pathology #Plant biochemistry and biosynthesis

paper · pdf · doi:10.1194/jlr.ra120001006

Abstract

synergistically exacerbated hepatocyte ER stress. Our data show a critical role for mevalonate-derived dolichol in the liver and suggest that dolichol depletion is at least partially responsible for ER stress and apoptosis upon potent Hmgcr inhibition.

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