「総合型地域スポーツクラブ」設立と地域づくりに関する研究--地域スポーツクラブが生む地域社会の活力と再生の可能性

2008/01/01 by Eric L. Simpson, Miguel Villarreal, Brett Jepson +15 · 25 citations
Medicine · Immunology and Microbiology · #Dermatology and Skin Diseases #Dermatology and Skin Diseases #Psoriasis: Treatment and Pathogenesis

paper · pdf · doi:10.1016/j.jid.2018.03.1517

Abstract

Patients with atopic dermatitis (AD) are commonly colonized with Staphylococcus aureus (AD S. aureus⁺), but what differentiates this group from noncolonized AD patients (AD S. aureus^-) has not been well studied. To evaluate whether these two groups have unique phenotypic or endotypic features, we performed a multicenter, cross-sectional study enrolling AD S. aureus⁺ (n = 51) and AD S. aureus^- (n = 45) participants defined by the presence or absence of S. aureus by routine culture techniques and nonatopic, noncolonized control individuals (NA S. aureus^-) (n = 46). Filaggrin (FLG) genotypes were determined, and disease severity (Eczema Area and Severity Index, Rajka-Langeland Severity Score, Investigator's Global Assessment score, Numerical Rating Scale, and Dermatology Life Quality Index) was captured. Skin physiology was assessed (transepidermal water loss [TEWL], stratum corneum integrity, hydration, and pH), and serum biomarkers were also measured. We found that AD S. aureus⁺ patients had more severe disease based on all scoring systems except itch (Numerical Rating Scale), and they had higher levels of type 2 biomarkers (eosinophil count, tIgE, CCL17, and periostin). Additionally, AD S. aureus⁺ patients had significantly greater allergen sensitization (Phadiatop and tIgE), barrier dysfunction (TEWL and stratum corneum integrity), and serum lactate dehydrogenase (LDH) than both the AD S. aureus^- and NA S. aureus^- groups. FLG mutations did not associate with S. aureus⁺ colonization. In conclusion, adult patients with AD who are colonized on their skin with S. aureus have more severe disease, greater type 2 immune deviation, allergen sensitization, barrier disruption, and LDH level elevation than noncolonized patients with AD.

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