2025/04/09 by Georgios N. Stamatas, Richard A. Insel, Nikolaj Sørensen +6 · 1 voice
Medicine · Health Professions · #Dermatology and Skin Diseases #Food Allergy and Anaphylaxis Research #Neonatal skin health care
paper · pdf · doi:10.1016/j.jid.2025.03.017
openalex publication_date 2025/04/09 · openalex created_date 2025/04/10 · openalex updated_date 2026/07/22
The rising incidence of atopic dermatitis (AD) prompted research into potential risk factors (Paller et al, 2024). Although family history and genetic factors, notably mutations of the FLG gene and others, are key (Palmer et al, 2006), the role of the skin microbiome as an early risk factor is poorly understood, despite its well-known role once the disease has been established (Demessant-Flavigny et al, 2023; Kong et al, 2012). Although early-life Staphylococcus aureus dominance is suspected to associate with future AD manifestation (Meylan et al, 2017; Rapin et al, 2023), controversies exist regarding S aureus as a definitive biomarker due to timing, specificity, and strain variability concerns (Byrd et al, 2017; Kennedy et al, 2017).