2026/08/03 by Garrett A. Kukier, Charles E. Diesendruck, Diptarka Hait +2 · 1 voice
Physics and Astronomy · Materials Science · #Force Microscopy Techniques and Applications #Mechanical and Optical Resonators #Luminescence and Fluorescent Materials #Chemiluminescence #Bond cleavage #Decomposition #Thermal decomposition #Mechanochemistry #Thermal #Kinetics
paper · doi:10.1021/jacs.6c07677
openalex publication_date 2026/08/03 · openalex created_date 2026/08/05 · openalex updated_date 2026/08/06
Abstract 1,2-Dioxetanes are well-known for their chemiluminescent decomposition initiated by O–O bond scission. Under thermal conditions, this chemiluminescence has been used for molecular imaging, while mechanochemical triggering of chemiluminescence can be a powerful tool for studying stress in materials. It has been widely assumed that mechanochemical activation follows the same O–O scission pathway as the thermal case. However, our first-principles simulations of the mechanochemically triggered decomposition of 1,2-dioxetane show that the traditional O–O scission pathway is largely insensitive to applied force. Instead, a thermally inaccessible C–C bond scission pathway is stabilized by applied force and becomes energetically favored above a critical force (∼1.8–3.0 nN). This force-induced mechanistic switch is robust across various pulling directions and substituents, including the experimentally tested adamantyl derivative. These findings establish a new, fundamentally force-dependent pathway for chemiluminescence. They demonstrate that mechanical force can be used not only to accelerate a reaction, but to fundamentally change its mechanism. This presents significant opportunities for new mechanophore design and mechanochemical sensing applications.