Quantum Chemistry on Graphical Processing Units. 3. Analytical Energy Gradients, Geometry Optimization, and First Principles Molecular Dynamics

2009/08/25 by Ivan S. Ufimtsev, Todd J. Martı́nez · 16 citations
Chemistry · Physics and Astronomy · #Advanced Chemical Physics Studies #Mass Spectrometry Techniques and Applications #Spectroscopy and Quantum Chemical Studies

paper · doi:10.1021/ct9003004

openalex publication_date 2009/08/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/12

Abstract

We demonstrate that a video gaming machine containing two consumer graphical cards can outpace a state-of-the-art quad-core processor workstation by a factor of more than 180× in Hartree-Fock energy + gradient calculations. Such performance makes it possible to run large scale Hartree-Fock and Density Functional Theory calculations, which typically require hundreds of traditional processor cores, on a single workstation. Benchmark Born-Oppenheimer molecular dynamics simulations are performed on two molecular systems using the 3-21G basis set - a hydronium ion solvated by 30 waters (94 atoms, 405 basis functions) and an aspartic acid molecule solvated by 147 waters (457 atoms, 2014 basis functions). Our GPU implementation can perform 27 ps/day and 0.7 ps/day of ab initio molecular dynamics simulation on a single desktop computer for these systems.

Citations

• Graphical Processing Units for Quantum Chemistry
• General atomic and molecular electronic structure system
• Quantum Chemistry on Graphical Processing Units. 2. Direct Self-Consistent-Field Implementation
• Quantum Chemistry on Graphical Processing Units. 1. Strategies for Two-Electron Integral Evaluation

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