Biglycan in the Skeleton

2020/07/06 by Vardit Kram, Reut Shainer, Priyam Jani +4 · 20 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Proteoglycans and glycosaminoglycans research #Connective tissue disorders research #Bone and Dental Protein Studies

paper · pdf · doi:10.1369/0022155420937371

Abstract

Small leucine rich proteoglycans (SLRPs), including Biglycan, have key roles in many organ and tissue systems. The goal of this article is to review the function of Biglycan and other related SLRPs in mineralizing tissues of the skeleton. The review is divided into sections that include Biglycan's role in structural biology, signaling, craniofacial and long bone homeostasis, remodeled skeletal tissues, and in human genetics. While many cell types in the skeleton are now known to be affected by Biglycan, there are still unanswered questions about its mechanism of action(s).

Citations

• The extracellular matrix at a glance
• Excess biglycan causes eyelid malformation by perturbing muscle development and TGF-α signaling
• Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues.

Cited by

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• Salivary biglycan-neo-epitope-BGN 262 : A novel surrogate biomarker for equine osteoarthritic sub-chondral bone sclerosis and to monitor the effect of short-term training and surface arena. [europepmc]
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• Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis. [europepmc]
• Regulation of Joint Tissues and Joint Function: Is There Potential for Lessons to Be Learned Regarding Regulatory Control from Joint Hypermobility Syndromes? [europepmc]
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• The regulation of pedicle initiation by androgens in sika deer (Cervus nippon). [europepmc]
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