2014/03/06 by Elspeth F. Garman · 1 citation
Materials Science · Biochemistry, Genetics and Molecular Biology · Chemistry · #Enzyme Structure and Function #Protein Structure and Dynamics #Biochemical and Molecular Research #Biomolecule #Macromolecule #Nanotechnology #Function (biology) #Biomolecular structure #Computer science #Chemistry #Materials science #Protein structure #Biology #Evolutionary biology #Biochemistry
paper · doi:10.1126/science.1247829
openalex publication_date 2014/03/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23
The three-dimensional structures of large biomolecules important in the function and mechanistic pathways of all living systems and viruses can be determined by x-ray diffraction from crystals of these molecules and their complexes. This area of crystallography is continually expanding and evolving, and the introduction of new methods that use the latest technology is allowing the elucidation of ever larger and more complex biological systems, which are now becoming tractable to structure solution. This review looks back at what has been achieved and forward at how current and future developments may allow technical challenges to be overcome.