2020/12/11 by Jiawu Li, Lulu Yang, Lin Ma +2 · 16 citations
Engineering · Medicine · #Area under the curve #Contrast-enhanced ultrasound #Diagnostic odds ratio #Hepatocellular Carcinoma Treatment and Prognosis #Hepatocellular carcinoma #Internal medicine #Liver Disease Diagnosis and Treatment #Malignancy #Medicine #Meta-analysis #Radiology #Receiver operating characteristic #Ultrasound #Ultrasound and Hyperthermia Applications
paper · doi:10.1055/a-1309-1568
published in Ultraschall in der Medizin - European Journal of Ultrasound 42(02), 187-193 (Georg Thieme Verlag)
crossref issued 2020/12/11 · crossref published 2020/12/11 · crossref published-online 2020/12/11 · openalex publication_date 2020/12/11 · crossref created 2020/12/12 · crossref published-print 2021/04/01 · crossref deposited 2021/04/12 · openalex created_date 2025/10/10 · crossref indexed 2026/07/31 · openalex updated_date 2026/08/04
OBJECTIVES: The American College of Radiology (ACR) contrast-enhanced ultrasound liver imaging reporting and data system (CEUS LI-RADS), which includes diagnostic criteria for hepatocellular carcinoma (HCC) and other hepatic malignancies (OM), is increasingly used in clinical practice. This study performed a meta-analysis to assess the diagnostic accuracy of CEUS LI-RADS for differentiating between HCC and OM in high-risk patients. METHODS: PubMed, Embase (Ovid), and Cochrane (CENTRAL) were searched for relevant studies. All studies that reported the percentage of HCC and OM in the LI-RADS categories were included. Random-effects models were used to calculate the pooled sensitivity and specificity, diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve. RESULTS: Eight studies involving 4215 focal liver lesions were included in the final analysis. The pooled sensitivity and specificity of the LR-5 criteria for HCC were 0.71 (95 % CI, 0.69-0.72) and 0.88 (0.85-0.91), respectively, the DOR was 18.36 (7.41-45.52), and the area under the SROC curve (AUC) was 0.8128. The pooled sensitivity and specificity of the LR-M criteria for OMs were 0.85 (0.81-0.88) and 0.86 (0.85-0.87), the DOR was 27.82 (11.83-65.40), respectively, and the SROC AUC was 0.9098. CONCLUSION: The CEUS LI-RADS can effectively distinguish HCC from other hepatic malignancy in high-risk patients based on LR-5 criteria and LR-M criteria. However, further studies are needed for validation due to the limited number of included studies and the potential heterogeneity among the included studies.