Cellular cholesterol homeostasis and Alzheimer's disease

2017/03/16 by Ta‐Yuan Chang, Yoshio Yamauchi, Mazahir T. Hasan +1 · 1 citation
Medicine · Computer Science · Chemistry · #Alzheimer's disease research and treatments #Cholesterol and Lipid Metabolism #Computational Drug Discovery Methods #Apolipoprotein E #Neuroinflammation #Cholesterol #Homeostasis #Amyloid precursor protein #Amyloid (mycology) #Alzheimer's disease #Dementia #Apolipoprotein B #Biology #Chemistry #Biochemistry #Cell biology #Internal medicine #Disease #Medicine

paper · doi:10.1194/jlr.r075630

openalex publication_date 2017/03/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23

Abstract

) potential lipid-based therapeutic targets to treat AD. At the end, we recommend several research topics that we believe would help in better understanding the connection between cholesterol and AD for further investigations.

Citations

• Oxysterol biosynthetic enzymes
• The Acyl-Coenzyme A: Cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid Pathology in Aged Amyloid Precursor Protein Transgenic Mice
• Cholesterol metabolism in neurons and astrocytes
• Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
• 24(S)‐hydroxycholesterol is actively eliminated from neuronal cells by ABCA1
• Regulation of HMG-CoA reductase in mammals and yeast
• LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies
• LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins
• Hearing Loss and Hair Cell Death in Mice Given the Cholesterol-Chelating Agent Hydroxypropyl-β-Cyclodextrin
• Acyl-coenzyme A:cholesterol acyltransferases

Cited by

• Apolipoprotein [wikipedia]

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