2009/01/14 by Ta-Yuan Chang, Ta‐Yuan Chang, Bo-Liang Li +3
Biochemistry, Genetics and Molecular Biology · Medicine · #Cholesterol and Lipid Metabolism #Lipid metabolism and biosynthesis #Peroxisome Proliferator-Activated Receptors
paper · doi:10.1152/ajpendo.90926.2008
openalex publication_date 2009/01/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
The enzymes acyl-coenzyme A (CoA):cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues. This chapter summarizes the current knowledge on ACAT-related research in two areas: 1) ACAT genes and proteins and 2) ACAT enzymes as drug targets for atherosclerosis and for Alzheimer's disease.