T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.
1996/06/01 by F Fossiez, François Fossiez, O Djossou +30 · 1,520 citations
Immunology and Microbiology · Medicine · #Biochemistry #Biology #CAR-T cell therapy research #Cell biology #Cytokine #Cytotoxic T cell #Haematopoiesis #Immune system #Immunology #Immunotherapy and Immune Responses #Inflammation #Interleukin #Interleukin 15 #Interleukin 21 #Interleukin 3 #Molecular biology #Monoclonal and Polyclonal Antibodies Research #Proinflammatory cytokine #Stem cell #T cell
paper · pdf · doi:10.1084/jem.183.6.2593
published in The Journal of Experimental Medicine 183(6), 2593-2603 (Rockefeller University Press)
openalex publication_date 1996/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Abstract
Analysis of the cDNA encoding murine interleukin (IL) 17 (cytotoxic T lymphocyte associated antigen 8) predicted a secreted protein sharing 57% amino acid identity with the protein predicted from ORF13, an open reading frame of Herpesvirus saimiri. Here we report on the cloning of human IL-17 (hIL-17), the human counterpart of murine IL-17. hIL-17 is a glycoprotein of 155 amino acids secreted as an homodimer by activated memory CD4+ T cells. Although devoid of direct effects on cells of hematopoietic origin, hIL-17 and the product of its viral counterpart, ORF13, stimulate epithelial, endothelial, and fibroblastic cells to secrete cytokines such as IL-6, IL-8, and granulocyte-colony-stimulating factor, as well as prostaglandin E2. Furthermore, when cultured in the presence of hIL-17, fibroblasts could sustain the proliferation of CD34+ hematopoietic progenitors and their preferential maturation into neutrophils. These observations suggest that hIL-17 may constitute (a) an early initiator of the T cell-dependent inflammmatory reaction; and (b) an element of the cytokine network that bridges the immune system to hematopoiesis.
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