Diseases that may benefit from manipulating the Th17 pathway

2009/03/01 by Pierre Miossec · 28 citations
Immunology and Microbiology · Medicine · #Autoimmune Bullous Skin Diseases #Bioinformatics #Biology #Disease #Gene #Genetics #Human disease #Immunodeficiency and Autoimmune Disorders #Immunology #Inflammation #Inflammatory bowel disease #Interleukin 17 #Internal medicine #Medicine #Psoriasis #Psoriasis: Treatment and Pathogenesis #Rheumatoid arthritis

paper · doi:10.1002/eji.200839088

published in European Journal of Immunology 39(3), 667-669 (Wiley)

openalex publication_date 2009/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05

Abstract

The discovery of IL-17 and of the Th17 pathway has been a step in the classification of human diseases. Th17 targeting appears rather straightforward in diseases associated with inflammation and matrix destruction, such as rheumatoid arthritis, psoriasis, and Crohn's disease. In other conditions where IL-17 is expressed and Th17 activated, it is unclear whether this is a primary or secondary event, making the use of Th17 inhibitors less obvious.

Cited by

• Cytokines in chronic rheumatic diseases: is everything lack of homeostatic balance? [europepmc]
• Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. [europepmc]
• Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases. [europepmc]
• Retinoic Acid Receptor-Related Receptor Alpha Ameliorates Autoimmune Arthritis via Inhibiting of Th17 Cells and Osteoclastogenesis. [europepmc]
• Chitosan siRNA Nanoparticles Produce Significant Non-Toxic Functional Gene Silencing in Kidney Cortices. [europepmc]
• Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhage. [europepmc]

Related

• The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases
• IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages
• IL-17 in inflammatory skin diseases psoriasis and hidradenitis suppurativa
• Interleukin‐17‐producing γδ T (γδ17) cells in inflammatory diseases
• IL-17 and Th17 Cells