Human Apolipoprotein D Gene: Gene Sequence, Chromosome Localization, and Homology to the α 2u -Globulin Superfamily

1987/06/01 by Dennis Drayna, John W. McLean, Karen L. Wion +3 · 5 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Blood Coagulation and Thrombosis Mechanisms #Protease and Inhibitor Mechanisms #Cell Adhesion Molecules Research #Gene #Homology (biology) #Intron #Exon #Genetics #Biology #Coding region #Untranslated region #Molecular biology #Messenger RNA

paper · doi:10.1089/dna.1987.6.199

openalex publication_date 1987/06/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/06/24

Abstract

The exons and bordering intron nucleotides of the human apolipoprotein D (apo D) gene have been sequenced. The protein-coding portion of the gene is divided into five exons which span approximately 12,000 bp. At least one intron interrupts the 5' untranslated region. The gene has been localized to the p14.2----qter region of human chromosome 3. Apo D shares homology with the alpha 2u-globulin superfamily of genes, including approximately 25% amino acid homology with human retinol-binding protein (RBP). Similarity of intron locations in both apo D and RBP suggests that these two genes derived from a common ancestor.

Citations

• Cloning and expression of human apolipoprotein D cDNA.
• A cholesteryl ester transfer complex in human plasma.
• DNA sequencing with chain-terminating inhibitors

Cited by

• Molecular Cloning of the Mouse Apolipoprotein D Gene and Its Upregulated Expression in Niemann-Pick Disease Type C Mouse Model
• Apolipoprotein D interacts with the long form leptin receptor: a hypothalamic function in the control of energy homeostasis
• Apolipoprotein D Gene Polymorphism: A New Genetic Marker for Type 2 Diabetic Subjects in Nauru and South India
• Multiple RFLPs at the human apolipoprotein D (APOD) locus
• Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African‐Americans
• Apolipoprotein D [wikipedia]