2010/01/01 by L. Machet, A. Maruani, Brigitte Arbeille +4 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Dermatological and Skeletal Disorders #Skin Diseases and Diabetes #Hypertrophic osteoarthropathy and related conditions #Cutis laxa #Medicine #Immunogold labelling #Pathology #Monoclonal gammopathy #Dermis #Reticular connective tissue #Ultrastructure #Monoclonal antibody #Monoclonal #Dermatology #Antibody #Immunology
paper · pdf · doi:10.2340/00015555-0887
openalex publication_date 2010/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/06/11
Acquired cutis laxa is an uncommon disorder sometimes associated with monoclonal gammopathy and multiple myeloma, although the mechanism of this link is unclear. We report here a case of a 34-year-old man with generalized acquired cutis laxa and monoclonal light chain disease with renal and neurological involvement. Electron microscopy examination of a skin sample revealed shortened and fragmented elastic fibres in the reticular dermis and normal collagen bundles. Immunogold labelling revealed anti-lambda antibodies closely bound to the microfibrillar component of elastic fibres, thus supporting a causal relationship between monoclonal gammopathy and the changes in skin elasticity.