2012/01/09 by Biswarup Pathak, Henrik Löfås, Jariyanee Prasongkit +3 · 1 citation
Engineering · Biochemistry, Genetics and Molecular Biology · Chemistry · #Nanopore and Nanochannel Transport Studies #Advanced biosensing and bioanalysis techniques #Electrochemical Analysis and Applications #Nanopore #Nucleobase #DNA #Electrode #Nucleic acid #Nanotechnology #Surface modification #Molecule #Materials science #Nanopore sequencing #Hydrogen bond #Combinatorial chemistry #Chemistry #DNA sequencing #Organic chemistry #Biochemistry
paper · doi:10.1063/1.3673335
openalex publication_date 2012/01/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
We have studied the effect of double-functionalization on gold electrodes for improving nanopore-based DNA sequencing. The functionalizing molecular probes are, respectively, capable of temporarily forming hydrogen bonds with both the nucleobase part and the phosphate group of the target DNA, thus potentially minimizing the structural fluctuations of a single-stranded DNA molecule passing between the gold electrodes. The results of our first-principles study indicate that the proposed setup yields current signals that differ by at least 1 order of magnitude for the four different nucleic acid bases, thus offering the possibility to electrically distinguish them.