1985/09/01 by Clara D. Bloomfield, RICHARD D. BRUNNING · 1 citation
Medicine · #Acute Myeloid Leukemia Research #Chronic Lymphocytic Leukemia Research #Acute Lymphoblastic Leukemia research #Medicine #Acute megakaryoblastic leukemia #Leukemia #Acute leukemia #Megakaryocyte #Lineage (genetic) #Myelofibrosis #Internal medicine #Bone marrow #Gene #Biology #Genetics
paper · doi:10.7326/0003-4819-103-3-450
openalex publication_date 1985/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
Editorials1 September 1985FAB M7: Acute Megakaryoblastic Leukemia—Beyond MorphologyCLARA D. BLOOMFIELD, M.D., RICHARD D. BRUNNING, M.D.CLARA D. BLOOMFIELD, M.D., RICHARD D. BRUNNING, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-103-3-450 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe French-American-British (FAB) leukemia cooperative study group, in this issue (1), adds another category of acute nonlymphocytic leukemia to their classification: acute leukemia of megakaryocyte lineage, or M7. As with prior FAB categories, M7 defines a type of leukemia that has been recognized for many years (2). Recently, as a result of developments in ultrastructural cytochemistry and immunologic phenotyping, acute leukemias of megakaryocytic lineage have been diagnosed increasingly (3-13); at least one group has reported that this type accounts for more than 10% of acute nonlymphocytic leukemias (10). Although a distinct clinical syndrome has not been delineated, it has been...References1. BENNETTCATOVSKYDANIEL JDM. Criteria for the diagnosis of acute leukemia of megakaryocyte lineage (M7): a report of the French-American-British Cooperative Group. Ann Intern Med. 1985;103:460-2. LinkGoogle Scholar2. VON BOROSKARENYI JA. Über einen Fall von akuter Megakaryoblastenleukämie, zugleich einige Bemerkungen zum Problem der akuten Leukämie. Z Klin Med. 1931;118:697-718. Google Scholar3. FLANDRINDANIELVALENSISCHAISONBRETON-GORIUS GMFGJ. Leucémie aiguë à mégacaryoblastes: étude clinique et morphologique de 11 observations. Actual Hematol. 1977;11:200-12. Google Scholar4. DEN OTTOLANDERTE VELDEBREDEROO GJP. Megakaryoblastic leukaemia (acute myelofibrosis): a report of three cases. Br J Haematol. 1979;42:9-20. CrossrefMedlineGoogle Scholar5. BAINCATOVSKYO'BRIEN BDM. Megakaryoblastic leukemia presenting as acute myelofibrosis—a study of four cases with the plateletperoxidase reaction. Blood. 1981;58:206-13. CrossrefMedlineGoogle Scholar6. SULTONSIGAUXIMBERTREYES CFMF. Acute myelodysplasia with myelofibrosis: a report of eight cases. Br J Haematol. 1981;49:11-6. CrossrefMedlineGoogle Scholar7. BEVANROSEGREAVES DMM. Leukaemia of platelet precursors: diverse features in four cases. Br J Haematol. 1982;51:147-64. CrossrefMedlineGoogle Scholar8. MIRCHANDANIPALUTKE IM. Acute megakaryoblastic leukemia. Cancer. 1983;50:2866-72. CrossrefGoogle Scholar9. CHANBRYNESKIM WRT. Acute megakaryoblastic leukemia in early childhood. Blood. 1983;62:92-8. CrossrefMedlineGoogle Scholar10. HUANGLINICHOLSYOUNGKATZMANN MCWJJ. 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CrossrefMedlineGoogle Scholar16. BENNETTCATOVSKYDANIEL JDM. Proposed revised criteria for the classification of acute myeloid leukemia. Ann Intern Med. 1985;103. (In press). LinkGoogle Scholar17. ARTHURBLOOMFIELD DC. Partial deletion of the long arm of chromosome 16 and bone marrow eosinophilia in acute nonlymphocytic leukemia: a new association. Blood. 1983;61:994-8. CrossrefMedlineGoogle Scholar18. Fourth International Workshop on Chromosomes in Leukemia, 1982: clinical significance of chromosomal abnormalities in acute nonlymphoblastic leukemia. Cancer Genet Cytogenet. 1984;11:332-50. CrossrefMedlineGoogle Scholar19. SOBOLROYSTONLEBIEN RIT. Adult acute lymphoblastic leukemia phenotypes defined by monoclonal antibodies. Blood. 1985;65:730-5. CrossrefMedlineGoogle Scholar20. KALWINSKYROBERSONDAHL DPG. Clinical relevance of lymphoblast biological features in children with acute lymphoblastic leukemia. J Clin Oncol. 1985;3:477-84. CrossrefMedlineGoogle Scholar21. Third International Workshop on Chromosomes in Leukemia: chromosomal abnormalities and their clinical significance in acute lymphoblastic leukemia. Cancer Res. 1983;43:868-73. MedlineGoogle Scholar22. BRETON-GORIUSVAN HAEKEPRYZWANSKY JDK. Simultaneous detection of membrane markers with monoclonal antibodies and peroxidatic activities in leukaemia: ultrastructural analysis using a new method of fixation preserving the platelet peroxidase. Br J Haematol. 1984;58:447-58. CrossrefMedlineGoogle Scholar23. SCHREEDERPRCHALPARMLEYCARROLLGEWIRTZHOFFMAN MJRAAR. An acute myeloproliferative disorder characterized by myelofibrosis and blast cells that express phenotypic properties associated with multiple hematopoietic lineages. Am J Clin Pathol. 1985;83:114-21. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Minnesota Health Sciences Center Minneapolis, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPediatric Acute Myeloid Leukemia—Past, Present, and FutureEpigenetic and Genetic Alterations in LeukemiaClinical Utility of Next-Generation Sequencing in Acute Myeloid LeukemiaLymphoma and LeukaemiaAcute myeloid leukemiaHematopoietic stem cell transplantation for de novo acute megakaryocytic leukemia in first complete remission: a retrospective study of the European Group for Blood and Marrow Transplantation (EBMT)Biology, clinical, and hematologic features of acute megakaryoblastic leukemia in childrenBiology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experienceCongenital Acute Megakaryoblastic Leukemia (M7) With Chromosomal t(l;22)(p13;q13) Translocation in a Set of Identical TwinsAcute Megakaryoblastic Leukemia: Importance of Bone Marrow Biopsy in DiagnosisAggressive polychemotherapy for acute myelofibrosisAcute Megakaryocytic Leukemia (M7) in ChildrenAcute Megakaryocytic LeukemiaCytochemistry and Immunocytochemistry in Bone Marrow Examination: Contemporary Techniques for the Diagnosis of Acute Leukemia and Myelodysplastic Syndromes: A Combined ApproachMonosomy 5 in acute megakaryoblastic leukemiaA prospective trial of the treatment of acute megakaryoblastic leukaemiaAcute megakaryocytic leukemia. Flow cytometric analysis of DNA content at diagnosis and during the course of therapyTreatment of Acute Megakaryocytic LeukemiaWILLIAM R. FRIEDENBERG, M.D., JOSEPH J. MAZZA, M.D., JOHN D. HINES, M.D.The Diagnosis of Megakaryoblastic LeukemiaLAURENCE CORASH, M.D., JAY H. BECKSTEAD, M.D. 1 September 1985Volume 103, Issue 3Page: 450-452KeywordsAcute myeloid leukemiaCytochemistryMegakaryocytesResearch funding ePublished: 1 December 2008 Issue Published: 1 September 1985 PDF downloadLoading ...