2012/04/05 by Ana González, B Maceira, Estefanía Pérez +3 · 1 citation
Medicine · Biochemistry, Genetics and Molecular Biology · #Chronic Kidney Disease and Diabetes #Pancreatic function and diabetes #Diabetes and associated disorders #End stage renal disease #Diabetes mellitus #Disease #Medicine #Biology #Internal medicine #Endocrinology
paper · doi:10.1089/gtmb.2011.0207
openalex publication_date 2012/04/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/22
AIMS: Type 1 and type 2 diabetes, complicated with renal disease, have a significantly higher incidence in the Canary Islands than in mainland Spain and other European countries. Present-day Canarian inhabitants consist of a mixed population with North African indigenous and European colonizer ancestors who have rapidly evolved from a rural to an urban life style. The aim of this work was to assess the possible role of genetic and environmental factors on diabetes-related end-stage renal disease incidence in the Canary Islands. RESULTS: For both types of diabetes there is an ethnic susceptibility increased by diabetes family history. Whereas the Y-chromosome does not play a significant role, mitochondrial DNA (mtDNA) haplogroup differences point to a maternal origin for this ethnic predisposition, confirming susceptible and protective effects for haplogroups J and T, respectively. In addition, urban life style seems to be an additional risk factor for type 1 diabetes. CONCLUSIONS: The maternal ethnic predisposition to diabetes complicated with kidney disease detected in the Canary Islands signals mtDNA and X-chromosome markers as the best candidates to uncover the genetic predisposition to this disease.