Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls

2007/06/01 by Patrick F. Chinnery, Catherine Mowbray, Sheila K. Patel +6 · 3 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Mitochondrial Function and Pathology #Liver Disease Diagnosis and Treatment #Metabolism and Genetic Disorders #Mitochondrial DNA #Haplogroup #Type 2 diabetes #Human mitochondrial DNA haplogroup #Genetics #Diabetes mellitus #Biology #Population #Mitochondrion #Haplotype #Medicine #Bioinformatics #Gene #Endocrinology #Genotype #Environmental health

paper · pdf · doi:10.1136/jmg.2007.048876

openalex publication_date 2007/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Mitochondria play a central role in the secretion of insulin by pancreatic beta-cells, and pathogenic mutations of mitochondrial DNA (mtDNA) can cause diabetes. The aetiology of type 2 diabetes has a strong genetic component, raising the possibility that genetic variants of mtDNA alter the risk of developing the disorder. Recent studies have produced conflicting results. By studying 897 UK cases of type 2 diabetes and 1010 population-matched controls, it is shown that European mtDNA haplogroups are unlikely to play a major role in the risk of developing the disorder.

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• Genetics, Environment, and Diabetes-Related End-Stage Renal Disease in the Canary Islands
• Mitochondrial Haplogroups N9 and G Are Associated with Metabolic Syndrome Among Human Immunodeficiency Virus-Infected Patients in China
• Haplogroup T (mtDNA) [wikipedia]

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