2002/01/01 by Neus Solé‐Morata, Carla García-Fernández, Vadim Urasin +6 · 1 citation
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Environmental Science · Medicine · #Bacteriophages and microbial interactions #Biology #Chromosomal and Genetic Variations #Chromosome #Evolutionary biology #Forensic and Genetic Research #Gene #Genealogy #Genetic diversity and population structure #Genetics #Herpesvirus Infections and Treatments #History #Lineage (genetic) #Molecular biology #Virus-based gene therapy research #Y chromosome
paper · pdf · doi:10.1038/s41598-017-16271-y
openalex publication_date 2002/01/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/02
E-M183 (E-M81) is the most frequent paternal lineage in North Africa and thus it must be considered to explore past historical and demographical processes. Here, by using whole Y chromosome sequences from 32 North African individuals, we have identified five new branches within E-M183. The validation of these variants in more than 200 North African samples, from which we also have information of 13 Y-STRs, has revealed a strong resemblance among E-M183 Y-STR haplotypes that pointed to a rapid expansion of this haplogroup. Moreover, for the first time, by using both SNP and STR data, we have provided updated estimates of the times-to-the-most-recent-common-ancestor (TMRCA) for E-M183, which evidenced an extremely recent origin of this haplogroup (2,000-3,000 ya). Our results also showed a lack of population structure within the E-M183 branch, which could be explained by the recent and rapid expansion of this haplogroup. In spite of a reduction in STR heterozygosity towards the West, which would point to an origin in the Near East, ancient DNA evidence together with our TMRCA estimates point to a local origin of E-M183 in NW Africa.