Sequencing Y Chromosomes Resolves Discrepancy in Time to Common Ancestor of Males Versus Females

2013/08/01 by G. David Poznik, Brenna M. Henn, Muh-Ching Yee +8 · 23 citations
Biochemistry, Genetics and Molecular Biology · Arts and Humanities · #Forensic and Genetic Research #Genetic diversity and population structure #Forensic Anthropology and Bioarchaeology Studies #Haplogroup #Ancestor #Biology #Mitochondrial DNA #Most recent common ancestor #Phylogenetic tree #Genome #Evolutionary biology #Genetics #Chromosome #Lineage (genetic) #Gene #Haplotype #Allele #Geography

paper · doi:10.1126/science.1237619

openalex publication_date 2013/08/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Examining Y The evolution of human populations has long been studied with unique sequences from the nonrecombining, male-specific Y chromosome (see the Perspective by Cann ). Poznik et al. (p. 562 ) examined 9.9 Mb of the Y chromosome from 69 men from nine globally divergent populations—identifying population and individual specific sequence variants that elucidate the evolution of the Y chromosome. Sequencing of maternally inherited mitochondrial DNA allowed comparison between the relative rates of evolution, which suggested that the coalescence, or origin, of the human Y chromosome and mitochondria both occurred approximately 120 thousand years ago. Francalacci et al. (p. 565 ) investigated the sequence divergence of 1204 Y chromosomes that were sampled within the isolated and genetically informative Sardinian population. The sequence analyses, along with archaeological records, were used to calibrate and increase the resolution of the human phylogenetic tree.

Citations

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• Haplogroup A (Y-DNA) [wikipedia]
• Most recent common ancestor [wikipedia]