Genetics of type 1 diabetes

2017/11/02 by María J. Redondo, Andrea K. Steck, Alberto Pugliese · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Diabetes and associated disorders #Pancreatic function and diabetes #Diabetes Management and Research #Medicine #Diabetes mellitus #Type 2 diabetes #MEDLINE #Computational biology #Genetics #Endocrinology #Biology

paper · pdf · doi:10.1111/pedi.12597

openalex publication_date 2017/11/02 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Type 1 diabetes (T1D) results from immune-mediated loss of pancreatic beta cells leading to insulin deficiency. It is the most common form of diabetes in children, and its incidence is on the rise. This article reviews the current knowledge on the genetics of T1D. In particular, we discuss the influence of HLA and non-HLA genes on T1D risk and disease progression through the preclinical stages of the disease, and the development of genetic scores that can be applied to disease prediction. Racial/ethnic differences, challenges and future directions in the genetics of T1D are also discussed.

Citations

• The changing face of diabetes in youth: lessons learned from studies of type 2 diabetes
• Control of Regulatory T Cell Development by the Transcription Factor Foxp3
• Projections of Type 1 and Type 2 Diabetes Burden in the U.S. Population Aged <20 Years Through 2050

Cited by

• Type 1 diabetes [wikipedia]

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