Plasma lipoproteins: apolipoprotein structure and function.

1984/12/01 by Robert W. Mahley, T L Innerarity, S C Rall +1 · 1,159 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Chemistry · #Cancer, Lipids, and Metabolism #Diabetes, Cardiovascular Risks, and Lipoproteins #Lipoproteins and Cardiovascular Health #Apolipoprotein B #Lipoprotein #Biochemistry #Apolipoprotein C2 #Apolipoprotein E #Lipid metabolism #Metabolism #Chemistry #Function (biology) #Biology #Very low-density lipoprotein #Cholesterol #Genetics #Internal medicine #Medicine

paper · doi:10.1016/s0022-2275(20)34443-6

published in Journal of Lipid Research 25(12), 1277-1294 (Elsevier BV)

openalex publication_date 1984/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23

Abstract

Plasma lipoprotein metabolism is regulated and controlled by the specific apolipoprotein (apo-) constituents of the various lipoprotein classes. The major apolipoproteins include apoE, apoB, apoA-I, apoA-II, apoA-IV, apoC-I, apoC-II, and apoC-III. Specific apolipoproteins function in the regulation of lipoprotein metabolism through their involvement in the transport and redistribution of lipids among various cells and tissues, through their role as cofactors for enzymes of lipid metabolism, or through their maintenance of the structure of the lipoprotein particles. The primary structures of most of the apolipoproteins are now known, and various functional domains of these proteins are being mapped using selective chemical modification, synthetic peptides, and monoclonal antibodies. Furthermore, the establishment of structure-function relationships has been greatly advanced by the identification of genetically determined variants of specific apolipoproteins that are associated with a disorder of lipoprotein metabolism. Future studies will rely heavily on the use of recombinant DNA technology and site-specific mutagenesis to elucidate further the correlations between structure and function and the role of specific apolipoproteins in lipoprotein metabolism.

Citations

• The Metabolic Basis of Inherited Disease

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