2008/05/20 by Aurélien G. Dupuy, Emmanuelle Caron · 250 citations
Medicine · Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · #Cell Adhesion Molecules Research #Phagocytosis and Immune Regulation #Extracellular vesicles in disease #Integrin #Cell biology #Biology #Phagocytosis #Extracellular matrix #Actin cytoskeleton #Cytoskeleton #Integrin alpha M #CD49c #Collagen receptor #Cell #Biochemistry
paper · doi:10.1242/jcs.018036
published in Journal of Cell Science 121(11), 1773-1783 (The Company of Biologists)
openalex publication_date 2008/05/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
By linking actin dynamics to extracellular components, integrins are involved in a wide range of cellular processes that are associated with or require cytoskeletal remodelling and cell-shape changes. One such function is integrin-dependent phagocytosis, a process that several integrins are capable of mediating and that allows the binding and clearance of particles. Integrin-dependent phagocytosis is involved in a wide range of physiological processes, from the clearance of microorganisms and apoptotic-cell removal to extracellular-matrix remodelling. Integrin signalling is also exploited by microbial pathogens for entry into host cells. Far from being a particular property of specific integrins and specialised cells, integrin-dependent uptake is emerging as a general, intrinsic ability of most integrins that is associated with their capacity to signal to the actin cytoskeleton. Integrin-mediated phagocytosis can therefore be used as a robust model in which to study integrin regulation and signalling.