Integrin signalling at a glance

2008/12/31 by David S. Harburger, David A. Calderwood, David Calderwood · 31 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Cell Adhesion Molecules Research #Caveolin-1 and cellular processes #Receptor Mechanisms and Signaling

paper · doi:10.1242/jcs.018093

Abstract

Integrins are a major family of cell-surface-adhesion receptors that are expressed in all metazoans. They are heterodimers of noncovalently associated α and β subunits, each of which is a single-pass type I transmembrane protein ([Humphries et al., 2006][1]; [Hynes, 2002][2]). The specific binding

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