The molecular basis for tropomyosin isoform diversity

1991/09/01 by James P. Lees‐Miller, David M. Helfman · 9 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Actin #Biology #Cardiomyopathy and Myosin Studies #Cell #Cell biology #Computational biology #Diversity (politics) #Evolutionary biology #Function (biology) #Gene #Gene isoform #Genetic diversity #Genetics #Multicellular organism #Muscle Physiology and Disorders #RNA Research and Splicing #Tropomyosin

paper · doi:10.1002/bies.950130902

openalex publication_date 1991/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15

Abstract

The tropomyosins are a family of actin filament binding proteins. In multicellular animals, they exhibit extensive cell type specific isoform diversity. In this essay we discuss the genetic mechanisms by which this diversity is generated and its possible significance to cellular function.

Citations

• Alpha-tropomyosin gene organization. Alternative splicing of duplicated isotype-specific exons accounts for the production of smooth and striated muscle isoforms.
• Three novel brain tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene through the use of alternative promoters and alternative RNA processing.
• Isolation and characterization of a cDNA that encodes mouse fibroblast tropomyosin isoform 2.

Cited by

• Tropomyosin isoforms in intestinal mucosa: Production of autoantibodies to tropomyosin isoforms in ulcerative colitis☆☆☆★
• Tropomyosin isoforms in rat neurons: the different developmental profiles and distributions of TM-4 and TMBr-3 are consistent with different functions
• Characterization of TPM1 disrupted yeast cells indicates an involvement of tropomyosin in directed vesicular transport.
• Tissue-specific Tropomyosin Isoform Composition
• Differential regulation of tropomyosin isoform organization and gene expression in response to altered actin gene expression.
• Autoimmunity to tropomyosin isoforms in ulcerative colitis (UC) patients and unaffected relatives
• Seafood allergy: A comprehensive review of fish and shellfish allergens
• Isolation and sequencing of a novel tropomyosin isoform preferentially associated with colon cancer
• Tropomyosin [wikipedia]