2010/09/01 by Rachel R Caspi · 480 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Ocular Diseases and Behçet’s Syndrome #Inflammasome and immune disorders #Retinal and Optic Conditions #Autoimmunity #Uveitis #Immunology #Blinding #Inflammation #Pathogenesis #Medicine #Retinal #Immune system #Pathology #Ophthalmology
paper · pdf · doi:10.1172/jci42440
published in Journal of Clinical Investigation 120(9), 3073-3083 (American Society for Clinical Investigation)
openalex publication_date 2010/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Autoimmune and inflammatory uveitis are a group of potentially blinding intraocular inflammatory diseases that arise without a known infectious trigger and are often associated with immunological responses to unique retinal proteins. In the United States, about 10% of the cases of severe visual handicap are attributed to this group of disorders. As I discuss here, experimental models of ocular autoimmunity targeting retinal proteins have brought about a better understanding of the basic immunological mechanisms involved in the pathogenesis of uveitis and are serving as templates for the development of novel therapies.