2011/01/06 by T. Larson, Robert B. Nussenblatt, H. Nida Sen · 1 citation
Medicine · Immunology and Microbiology · #Ocular Diseases and Behçet’s Syndrome #Leptospirosis research and findings #Sarcoidosis and Beryllium Toxicity Research #Medicine #Rituximab #Infliximab #Daclizumab #Adalimumab #Chlorambucil #Etanercept #Azathioprine #Tacrolimus #Uveitis #Pharmacology #Tocilizumab #Clinical trial #Intensive care medicine #Immunology #Disease #Cyclophosphamide #Rheumatoid arthritis #Transplantation #Internal medicine #Chemotherapy #Tumor necrosis factor alpha #Lymphoma
paper · doi:10.1517/14728214.2011.537824
openalex publication_date 2011/01/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
INTRODUCTION: Uveitis is a challenging disease covering both infectious and noninfectious conditions. The current treatment strategies are hampered by the paucity of randomized controlled trials and trials comparing the efficacy of different agents. AREAS COVERED: This review describes the current and future treatments of uveitis. A literature search was performed in PUBMED from 1965 to 2010 on drugs treating ocular inflammation with emphasis placed on more recent, larger studies. Readers should gain a basic understanding of current treatment strategies beginning with corticosteroids and transitioning to steroid sparing agents. Steroid sparing agents include antimetabolites such as methotrexate, azathioprine and mycophenolate mofetil; calcineurin inhibitors which include cyclosporine, tacrolimus; alkylating agents which include cyclophosphamide and chlorambucil; and biologics which include the TNF-α inhibitors infliximab, adalimumab and etanercept and daclizumab, IFN-α(2a) and rituximab. EXPERT OPINION: Newer agents are typically formulated from existing drugs or developed based on new advances in immunology. Future treatment will require a better understanding of the mechanisms involved in autoimmune diseases and better delivery systems in order to provide targeted treatment with minimal side effects.