Bioactive Milk Peptides: A Prospectus

2000/06/01 by D.A. Clare, Debra A. Clare, H.E. Swaisgood +1 · 719 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · #Amino acid #Antimicrobial #Antimicrobial peptides #Biochemistry #Biology #Biotechnology #Casein #Chemistry #Insect Utilization and Effects #Meat and Animal Product Quality #Microbiology #Peptide #Protein Hydrolysis and Bioactive Peptides

paper · pdf · doi:10.3168/jds.s0022-0302(00)74983-6

published in Journal of Dairy Science 83(6), 1187-1195 (Elsevier BV)

openalex publication_date 2000/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

Bioactive peptides have been identified within the amino acid sequences of native milk proteins. Hydrolytic reactions, such as those catalyzed by digestive enzymes, result in their release. These peptides directly influence numerous biological processes evoking behavioral, gastrointestinal, hormonal, immunological, neurological, and nutritional responses. The specific bioreactions associated with each physiological class have been well characterized. Herein, we review the scientific literature and attempt to stimulate consideration of the continued use of bioactive peptides and their expanded development as a commercial product. Several applications have already evolved. For example, phosphopeptides derived from casein fractions are currently used as both dietary and pharmaceutical supplements. Potentially, the addition of bioactive peptides to food products could improve consumer safety as a result of their antimicrobial properties. Lastly, bioactive peptides may function as health care products, providing therapeutic value for either treatment of infection or prevention of disease.

Citations

• Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins

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• Bovine milk in human nutrition--a review. [europepmc]
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• Digestion of Protein in Premature and Term Infants. [europepmc]
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